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Article

A population genetics-phylogenetics approach to inferring natural selection in coding sequences.

PLoS genetics - 1 Dec 2011

Wilson Daniel J, Hernandez Ryan D, Andolfatto Peter, Przeworski Molly

Abstract excerpt

Through an analysis of polymorphism within and divergence between species, we can hope to learn about the distribution of selective effects of mutations in the genome, changes in the fitness landscape that occur over time, and the location of sites involved in key adaptations that distinguish modern-day species. We introduce a novel method for the analysis of variation in selection pressures within and between...

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Identifiers

PMID: 22144911
DOI: 10.1371/journal.pgen.1002395
PMCID: PMC3228810

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