The evolution of codon preferences in Drosophila: a maximum-likelihood approach to parameter estimation and hypothesis testing.

doi:10.1007/pl00006535

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Article

The evolution of codon preferences in Drosophila: a maximum-likelihood approach to parameter estimation and hypothesis testing.

Journal of molecular evolution - 1 Jul 1999

McVean G A, Vieira J

Abstract excerpt

Synonymous codon usage in related species may differ as a result of variation in mutation biases, differences in the overall strength and efficiency of selection, and shifts in codon preference-the selective hierarchy of codons within and between amino acids. We have developed a maximum-likelihood method to employ explicit population genetic models to analyze the evolution of parameters determining codon usage....

Topics

Amino Acids
Animals
Base Sequence
Codon
Drosophila
Drosophila melanogaster
Evolution, Molecular
Genetic Heterogeneity
Genetic Variation
Likelihood Functions
Models, Genetic
Models, Statistical
Mutation
Selection, Genetic
Species Specificity

Source

Open in PubMed

Identifiers

PMID: 10368435
DOI: 10.1007/pl00006535

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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