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Article

Isoform-specific mutations in the Caenorhabditis elegans heterochronic gene lin-14 affect stage-specific patterning.

Genetics - 1 Jan 2001

Reinhart B J, Ruvkun G

Abstract excerpt

The Caenorhabditis elegans heterochronic gene lin-14 specifies the temporal sequence of postembryonic developmental events. lin-14, which encodes differentially spliced LIN-14A and LIN-14B1/B2 protein isoforms, acts at distinct times during the first larval stage to specify first and second larval stage-specific cell lineages. Proposed models for the molecular basis of these two lin-14 gene activities have...

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Identifiers

PMID: 11139502
DOI: 10.1093/genetics/157.1.199
PMCID: PMC1461488

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