Article
The timing of lin-4 RNA accumulation controls the timing of postembryonic developmental events in Caenorhabditis elegans.
Developmental biology - 1 Jun 1999
Feinbaum R, Ambros V
Abstract excerpt
The lin-4 gene encodes a small RNA that is required to translationally repress lin-14 toward the end of the first larval stage of Caenorhabditis elegans development. To determine if the timing of LIN-14 protein down-regulation depends on the temporal profile of lin-4 RNA level, we analyzed the stage-specificity of lin-4 RNA expression during wild-type development and examined the phenotypes of transgenic worms...
Topics
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Down-Regulation
- Gene Expression Regulation, Developmental
- Genes, Helminth
- Helminth Proteins
- Immunohistochemistry
- Nuclear Proteins
- Phenotype
- Protein Biosynthesis
- RNA, Helminth
- RNA, Messenger