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Article

A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms.

eLife - 30 Mar 2020

Azzi Chiara, Aeschimann Florian, Neagu Anca, Großhans Helge

Abstract excerpt

Robust organismal development relies on temporal coordination of disparate physiological processes. In Caenorhabditis elegans, the heterochronic pathway controls a timely juvenile-to-adult (J/A) transition. This regulatory cascade of conserved proteins and small RNAs culminates in accumulation of the transcription factor LIN-29, which triggers coordinated execution of transition events. We report that two LIN-29...

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Identifiers

PMID: 32223899
DOI: 10.7554/eLife.53387
PMCID: PMC7105380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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A branched heterochronic pathway directs juvenile-to-adult transition through two LIN-29 isoforms.PMID 32223899Read ↗

let-7 miRNA and lin-46 mRNA are essential targets of the LIN28 RNA-binding protein in Caenorhabditis elegans developmental timing regulation.Semantic proximity Read ↗

<i>let-7</i> controls the transition to adulthood by releasing select transcriptional regulators from repression by LIN41Semantic proximity Read ↗

Timing mechanism of sexually dimorphic nervous system differentiationSemantic proximity Read ↗

Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans.Semantic proximity Read ↗

LIN28-mediated gene regulatory loops synchronize developmental transitions throughout organogenesisSemantic proximity Read ↗

<i>C. elegans</i> LIN-28 controls temporal cell-fate progression by regulating LIN-46 expression via the 5’UTR of <i>lin-46</i> mRNASemantic proximity Read ↗

The heterochronic gene Lin28 regulates amphibian metamorphosis through disturbance of thyroid hormone functionSemantic proximity Read ↗

The Caenorhabditis elegans heterochronic gene pathway controls stage-specific transcription of collagen genes.Semantic proximity Read ↗

Somatic gonad morphogenesis in C. elegans requires the heterochronic pathway acting through HBL-1.Semantic proximity Read ↗

LIN-42/PERIOD controls cyclical and developmental progression of C. elegans molts.Semantic proximity Read ↗

A developmental timer coordinates organism-wide microRNA transcriptionSemantic proximity Read ↗

The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.Semantic proximity Read ↗

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