Article
Higher risk of mismatch repair-deficient colorectal cancer in alpha(1)-antitrypsin deficiency carriers and cigarette smokers.
Molecular genetics and metabolism - 1 Dec 2000
Yang P, Cunningham J M, Halling K C, Lesnick T G, Burgart L J, Wiegert E M, Christensen E R, Lindor N M, Katzmann J A, Thibodeau S N
Abstract excerpt
Microsatellite instability (MSI) is a genomic alteration observed in 15-30% of colorectal cancer (CRC). Two MSI phenotypes have been defined for CRC: MSI-H is characterized by MSI at > or =30% of the examined loci and MSI-L by MSI at 1-30% of the loci. An absence of MSI at any examined loci has been defined as a microsatellite stable (MSS) phenotype. Current data suggest the majority of MSI tumors are the result...
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