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Article

Implications of Familial Colorectal Cancer Risk Profiles and Microsatellite Instability Status

24 Mar 2009

Abstract excerpt

PURPOSE: Estimating familial colorectal cancer (CRC) risk is clinically important in being able to discriminate between high- and low-risk groups. To quantify familial CRC risks associated with mismatch repair (MMR) deficient and microsatellite stable (MSS) tumors, we analyzed 2,941 population-based cases of CRC. PATIENTS AND METHODS: MMR status in CRCs was established by testing for microsatellite instability...

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PMID: 19307499
DOI: 10.1200/jco.2008.20.3364

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