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Article

Microsatellite instability in colorectal cancer

26 Oct 2010

Abstract excerpt

Approximately 20 percent of right-sided colon cancers and 5 percent of left-sided colon and rectal cancers have a deficient DNA mismatch repair system. This results in the widespread accumulation of mutations to nucleotide repeats, some of which occur within the coding regions of cancer-related genes such as TGFβRII and BAX. A standardized definition for microsatellite instability (MSI) based on the presence of...

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PMID: 21114775
DOI: 10.1111/j.1743-7563.2010.01335.x

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