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Article

Involvement of Chk1 kinase in prophase I arrest of Xenopus oocytes.

Developmental biology - 15 Mar 1999

Nakajo N, Oe T, Uto K, Sagata N

Abstract excerpt

Chk1 kinase, a DNA damage/replication G2 checkpoint kinase, has recently been shown to phosphorylate and inhibit Cdc25C, a Cdc2 Tyr-15 phosphatase, thereby directly linking the G2 checkpoint to negative regulation of Cdc2. Immature Xenopus oocytes are arrested naturally at the first meiotic prophase (prophase I) or the late G2 phase, with sustained Cdc2 Tyr-15 phosphorylation. Here we have cloned a Xenopus...

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Identifiers

PMID: 10068474
DOI: 10.1006/dbio.1998.9178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Involvement of Chk1 kinase in prophase I arrest of Xenopus oocytes.PMID 10068474Read ↗

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Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.Semantic proximity Read ↗

When more is less: heritable gain-of-function chk1 mutations impair human fertility.Semantic proximity Read ↗

A small increase in <i>CHEK1</i> activity leads to the arrest of the first zygotic division in humanSemantic proximity Read ↗

Oocyte Elimination Through DNA Damage Signaling from CHK1/CHK2 to p53 and p63Semantic proximity Read ↗

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