Article
Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.
Science (New York, N.Y.) - 22 Dec 2000
Ertekin-Taner N, Graff-Radford N, Younkin L H, Eckman C, Baker M, Adamson J, Ronald J, Blangero J, Hutton M, Younkin S G
Abstract excerpt
Plasma Abeta42 (amyloid beta42 peptide) is invariably elevated in early-onset familial Alzheimer's disease (AD), and it is also increased in the first-degree relatives of patients with typical late-onset AD (LOAD). To detect LOAD loci that increase Abeta42, we used plasma Abeta42 as a surrogate trait and performed linkage analysis on extended AD pedigrees identified through a LOAD patient with extremely high...
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