Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.

doi:10.1093/hmg/ddi041

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Article

Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.

Human molecular genetics - 1 Feb 2005

Ertekin-Taner Nilüfer, Ronald James, Feuk Lars, Prince Jonathan, Tucker Michael, Younkin Linda, Hella Maria, Jain Shushant, Hackett Alyssa, Scanlin Leah, Kelly Jason, Kihiko-Ehman Muthoni, Neltner Matthew, Hersh Louis, Kindy Mark, Markesbery William, Hutton Michael, de Andrade Mariza, Petersen Ronald C, Graff-Radford Neill, Estus Steve, Brookes Anthony J, Younkin Steven G

Abstract excerpt

Plasma amyloid beta protein (Abeta42) levels and late onset Alzheimer's disease (LOAD) have been linked to the same region on chromosome 10q. The PLAU gene within this region encodes urokinase-type plasminogen activator, which converts plasminogen to plasmin. Abeta aggregates induce PLAU expression thereby increasing plasmin, which degrades both aggregated and non-aggregated forms of Abeta. We evaluated single...

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Identifiers

PMID: 15615772
DOI: 10.1093/hmg/ddi041

Genes

PLAU
IDE

Variants

rs2227564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene.PMID 15615772Read ↗

Association of late-onset Alzheimer disease with a genotype of PLAU, the gene encoding urokinase-type plasminogen activator on chromosome 10q22.2.Semantic proximity Read ↗

A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease.Semantic proximity Read ↗

Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease.Semantic proximity Read ↗

Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.Semantic proximity Read ↗

Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta.Semantic proximity Read ↗

Gene Association Study of the Urokinase Plasminogen Activator and Its Receptor Gene in Alzheimer's Disease.Semantic proximity Read ↗

Association of VTN Genotype with Plasminogen Activator Inhibitor-1 Activity in Late-Onset Alzheimer's Disease.Semantic proximity Read ↗

Association of tagSNPs in the urokinase-plasminogen activator (PLAU) gene with Alzheimer's disease and associated quantitative traits.Semantic proximity Read ↗

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Two Rare Variants in PLAU and BACE1 Genes-Do They Contribute to Semantic Dementia Clinical Phenotype?Semantic proximity Read ↗

Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.Semantic proximity Read ↗

No association of a non-synonymous PLAU polymorphism with Alzheimer's disease and disease-related traits.Semantic proximity Read ↗

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