Article
Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2.
Human genetics - 1 Dec 2012
Ibrahim-Verbaas Carla A, Zorkoltseva Irina V, Amin Najaf, Schuur Maaike, Coppus Antonia M W, Isaacs Aaron, Aulchenko Yurii S, Breteler Monique M B, Ikram M Arfan, Axenovich Tatiana I, Verbeek Marcel M, van Swieten John C, Oostra Ben A, van Duijn Cornelia M
Abstract excerpt
Plasma concentrations of Aβ40 and Aβ42 rise with age and are increased in people with mutations that cause early-onset Alzheimer's disease (AD). Amyloid beta (Aβ) plasma levels were successfully used as an (endo)phenotype for gene discovery using a linkage approach in families with dominant forms...
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