Article
Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees.
Human molecular genetics - 1 Dec 2003
Ertekin-Taner Nilüfer, Ronald James, Asahara Hideaki, Younkin Linda, Hella Maria, Jain Shushant, Gnida Eugene, Younkin Samuel, Fadale Daniel, Ohyagi Yasumasa, Singleton Adam, Scanlin Leah, de Andrade Mariza, Petersen Ronald, Graff-Radford Neill, Hutton Michael, Younkin Steven
Abstract excerpt
Using plasma amyloid beta protein (Abeta42) levels as an intermediate, quantitative phenotype for late onset Alzheimer's disease (LOAD), we previously obtained significant linkage at approximately 80 cM on chromosome 10. Linkage to the same region was obtained independently in a study of affected LOAD sib-pairs. Together, these two studies provide strong evidence for a novel LOAD locus on chromosome 10 that acts...
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