Article
A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
American journal of human genetics - 1 Jan 2006
Grupe Andrew, Li Yonghong, Rowland Charles, Nowotny Petra, Hinrichs Anthony L, Smemo Scott, Kauwe John S K, Maxwell Taylor J, Cherny Sara, Doil Lisa, Tacey Kristina, van Luchene Ryan, Myers Amanda, Wavrant-De Vrièze Fabienne, Kaleem Mona, Hollingworth Paul, Jehu Luke, Foy Catherine, Archer Nicola, Hamilton Gillian, Holmans Peter, Morris Chris M, Catanese Joseph, Sninsky John, White Thomas J, Powell John, Hardy John, O'Donovan Michael, Lovestone Simon, Jones Lesley, Morris John C, Thal Leon, Owen Michael, Williams Julie, Goate Alison
Abstract excerpt
Strong evidence of linkage to late-onset Alzheimer disease (LOAD) has been observed on chromosome 10, which implicates a wide region and at least one disease-susceptibility locus. Although significant associations with several biological candidate genes on chromosome 10 have been reported, these findings have not been consistently replicated, and they remain controversial. We performed a chromosome 10-specific...
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