Article
Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees.
Genetic epidemiology - 1 Jul 2001
Ertekin-Taner N, Graff-Radford N, Younkin L H, Eckman C, Adamson J, Schaid D J, Blangero J, Hutton M, Younkin S G
Abstract excerpt
Plasma amyloid beta42 peptide (Abeta42) levels are significantly elevated in all genetic forms of early-onset Alzheimer's disease caused by familial Alzheimer's disease mutations or Down's syndrome. Moreover, recent studies have determined that both plasma Abeta42 and Abeta40 levels are significantly elevated in late-onset Alzheimer's disease (LOAD) patients, their cognitively normal first-degree relatives, and...
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