Article
No genetic association between polymorphisms in the Fyn kinase gene and age of schizophrenic onset.
Neuroscience letters - 29 May 2003
Ohnuma Tohru, Shibata Nobuto, Matsubara Yoichiro, Sato Satoshi, Yamashina Mitsuru, Arai Heii
Abstract excerpt
Since the mRNA level of Fyn, a neurodevelopmental molecule, expression had been reported to be increased in postmortem schizophrenic prefrontal cortex and showed a strong correlation with age of disease onset, we investigated whether the three polymorphisms of the Fyn gene on genomic DNA (-93A/G, IVS10+37T/C and Ex12+894T/G) also had an effect on clinical onset in 139 unrelated schizophrenics. A comparison of the...
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