Article
Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts.
Biological psychiatry - 15 Dec 2003
Schumann Gunter, Rujescu Dan, Kissling Christian, Soyka Michael, Dahmen Norbert, Preuss Ullrich W, Wieman Stefan, Depner Martin, Wellek Stefan, Lascorz Jesús, Bondy Brigitta, Giegling Ina, Anghelescu Ion, Cowen Michael S, Poustka Annemarie, Spanagel Rainer, Mann Karl, Henn Fritz A, Szegedi Armin
Abstract excerpt
BACKGROUND: Decreased sensitivity to and increased tolerance for the effects of alcohol is a phenotype, which was shown to be associated with an increased risk for alcoholism in humans and was observed in protein tyrosine kinase (PTK) fyn knockout mice. METHODS: We performed an association study of genetic variations of PTK fyn in 430 alcohol-dependent patients and 365 unrelated control subjects from two...
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