Article
Genetic association between -93A/G polymorphism in the Fyn kinase gene and alcohol dependence in Spanish men.
European psychiatry : the journal of the Association of European Psychiatrists - 1 Apr 2009
Pastor Isabel J, Laso F Javier, Inés Sandra, Marcos Miguel, González-Sarmiento Rogelio
Abstract excerpt
BACKGROUND: Fyn tyrosine kinase is a member of the Scr family that phosphorylates the NR2A and NR2B subunits of the NMDA receptors reducing the inhibitory effects of ethanol and therefore may regulate the individual sensitivity to ethanol. OBJECTIVES: To investigate whether there is any relationship between the polymorphism at position -93 of the Fyn kinase gene and the susceptibility to develop alcoholism....
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