Article
Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4+ T-helper cells.
The American journal of pathology - 1 Jan 1992
Spiegel H, Herbst H, Niedobitek G, Foss H D, Stein H
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) infection causes progressive depletion of CD4/HIV-receptor-positive T helper lymphocytes, ultimately leading to AIDS. The major HIV reservoir and site of T-helper cell infection in lymphoid tissues, however, has remained poorly defined. The authors used in situ hybridization in combination with immunohistologic labeling techniques to identify the phenotype of...
Topics
- Adult
- Antibodies, Monoclonal
- CD4 Antigens
- Dendritic Cells
- Female
- HIV Infections
- HIV-1
- Humans
- Immunohistochemistry
- Infant
- Lymphocyte Depletion