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The Spleen Is an HIV-1 Sanctuary During Combined Antiretroviral Therapy

31 Oct 2017

Abstract excerpt

Combined antiretroviral therapy (cART) does not eradicate HIV, which persists for years and can re-establish replication if treatment is stopped. The current challenge is identifying those tissues harboring virus through cART. Here, we used HIV env-nef single genome sequencing and HIV gag droplet digital PCR (ddPCR) to survey 50 tissues from five subjects on cART with no detectable plasma viral load at death. The...

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PMID: 29084441
DOI: 10.1089/aid.2017.0254

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