Article
Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1.
Journal of virology - 1 Jun 2008
Keele Brandon F, Tazi Loubna, Gartner Suzanne, Liu Yiling, Burgon Trever B, Estes Jacob D, Thacker Tyler C, Crandall Keith A, McArthur Justin C, Burton Gregory F
Abstract excerpt
Throughout the natural course of human immunodeficiency virus (HIV) infection, follicular dendritic cells (FDCs) trap and retain large quantities of particle-associated HIV RNA in the follicles of secondary lymphoid tissue. We have previously found that murine FDCs in vivo could maintain trapped virus particles in an infectious state for at least 9 months. Here we sought to determine whether human FDCs serve as...
Topics
- CD4-Positive T-Lymphocytes
- Coculture Techniques
- Dendritic Cells, Follicular
- Genotype
- HIV Infections
- HIV-1
- Humans
- Mutation
- Phylogeny
- Viral Proteins
- Virus Replication