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Article

Germinal Center T Follicular Helper Cells Are Highly Permissive to HIV-1 and Alter Their Phenotype during Virus Replication.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2016

Kohler Stephanie L, Pham Michael N, Folkvord Joy M, Arends Tessa, Miller Shannon M, Miles Brodie, Meditz Amie L, McCarter Martin, Levy David N, Connick Elizabeth

Abstract excerpt

HIV-1 replication is concentrated within CD4(+) T cells in B cell follicles of secondary lymphoid tissues during asymptomatic disease. Limited data suggest that a subset of T follicular helper cells (TFH) within germinal centers (GC) is highly permissive to HIV-1. Whether GC TFH are the major HIV-1 virus-producing cells in vivo has not been established. In this study, we investigated TFH permissivity to HIV-1 ex...

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Identifiers

PMID: 26873986
DOI: 10.4049/jimmunol.1502174
PMCID: PMC4779697

Genes

CXCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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