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Article

Follicular dendritic cell contributions to HIV pathogenesis.

Seminars in immunology - 1 Aug 2002

Burton Gregory F, Keele Brandon F, Estes Jacob D, Thacker Tyler C, Gartner Suzanne

Abstract excerpt

Early after infection, large quantities of HIV are trapped on follicular dendritic cells (FDCs) thus establishing a potent reservoir of infectious virus adjacent to highly susceptible CD4-bearing T lymphocytes. Throughout much of the disease course, active HIV infection is largely confined to sites surrounding FDCs suggesting that this microenvironment is highly conducive to infection. FDCs maintain HIV...

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PMID: 12163303
DOI: 10.1016/s1044-5323(02)00060-x

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