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Article

Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation.

Proceedings of the National Academy of Sciences of the United States of America - 19 Dec 2000

Yen H C, Chang E C

Abstract excerpt

The INT6 gene has been implicated in human breast cancer formation, but its function is unknown. We isolated an Int6 homolog from fission yeast, Yin6, by its binding to a conserved protein in the Ras pathway, Moe1. Yin6 and Moe1 converge on the same protein complex to promote microtubule instability/disassembly. Yin6 and Moe1 interact cooperatively: when either protein is absent, the other becomes mislocalized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11121040
DOI: 10.1073/pnas.97.26.14370
PMCID: PMC18925

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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