Article
L-selectin can mediate leukocyte rolling in untreated mesenteric venules in vivo independent of E- or P-selectin.
Blood - 1 Sept 1993
Ley K, Tedder T F, Kansas G S
Abstract excerpt
Granulocyte recruitment during the acute inflammatory response is initiated by their rolling along the endothelial lining of postcapillary venules. To determine whether expression of L-selectin alone is sufficient for rolling, the murine pre-B lymphocytic cell line 300.19, which does not bind E- or P-selectin, was transfected with human L-selectin cDNA, which led to stable L-selectin expression at a level similar...
Topics
- Animals
- Antibodies
- Cell Adhesion
- Cell Adhesion Molecules
- Cell Movement
- E-Selectin
- Endothelium, Vascular
- Female
- Granulocytes
- Humans
- L-Selectin
- Lectins