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Article

Lyphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune system.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 1996

Steeber D A, Green N E, Sato S, Tedder T F

Abstract excerpt

Lymphocyte trafficking across high endothelial venules (HEV) of peripheral lymph nodes (PLN) is dependent upon lymphocyte expression of L-selectin. Mice that lack this adhesion molecule provide an opportunity to determine the long-term role of L-selectin-mediated migration in the maintenance of leukocyte subpopulations. HEV in L-selectin-deficient mice were phenotypically, morphologically, and functionally...

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Identifiers

PMID: 8757614

Genes

PLN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Lyphocyte migration in L-selectin-deficient mice. Altered subset migration and aging of the immune system.PMID 8757614Read ↗

Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice.Semantic proximity Read ↗

T lymphocyte migration to lymph nodes is maintained during homeostatic proliferation.Semantic proximity Read ↗

Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment.Semantic proximity Read ↗

A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules.Semantic proximity Read ↗

Severe inflammatory defect and reduced viability in CD18 and E-selectin double-mutant mice.Semantic proximity Read ↗

Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice.Semantic proximity Read ↗

Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule-1 expression.Semantic proximity Read ↗

N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules.Semantic proximity Read ↗

Critical role of the alpha 4 integrin/VCAM-1 pathway in cerebral leukocyte trafficking in lupus-prone MRL/fas(lpr) mice.Semantic proximity Read ↗

Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins.Semantic proximity Read ↗

Regulation of L-selectin expression on cultured bone marrow leukocytes and their precursors.Semantic proximity Read ↗

Severely reduced neutrophil adhesion and impaired host defense against fecal and commensal bacteria in CD18-/-P-selectin-/- double null mice.Semantic proximity Read ↗

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