Article
Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins.
Cell - 23 Feb 1996
Frenette P S, Mayadas T N, Rayburn H, Hynes R O, Wagner D D
Abstract excerpt
We describe the phenotype of mice lacking both endothelial selectins after sequential ablation of the genes encoding P- and E-selectins. In contrast with the rather mild phenotypes observed in mice deficient in a single selectin gene, the doubly deficient mice present extreme leukocytosis, elevated cytokine levels, and alterations in hematopoiesis. Granulocytopoiesis is increased both in bone marrow and spleen,...
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