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Article

Mouse toxicity and cytokine release by verotoxin 1 B subunit mutants.

Infection and immunity - 1 Jan 2001

Wolski V M, Soltyk A M, Brunton J L

Abstract excerpt

The crystal structure of the verotoxin 1 (VT1) B subunit complexed with a globotriaosylceramide (Gb(3)) analogue showed the presence of three receptor binding sites per monomer. We wished to study the effects of altering the three sites, singly or in combination, on animal toxicity and cytokine induction in vitro. We found that while the site 1 and 2 mutants were modestly (two- to sevenfold) reduced in their...

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Identifiers

PMID: 11119557
DOI: 10.1128/IAI.69.1.579-583.2001
PMCID: PMC97923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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