Article
Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins.
The Journal of biological chemistry - 14 Apr 2006
Okuda Tetsuya, Tokuda Noriyo, Numata Shin-ichiro, Ito Masafumi, Ohta Michio, Kawamura Kumiko, Wiels Joelle, Urano Takeshi, Tajima Orie, Furukawa Keiko, Furukawa Koichi
Abstract excerpt
To examine whether globotriaosylceramide (Gb3/CD77) is a receptor for verotoxins (VTs) in vivo, sensitivity of Gb3/CD77 synthase null mutant mice to VT-2 and VT-1 was analyzed. Although wild-type mice died after administration of 0.02 microg of VT-2 or 1.0 microg of VT-1, the mutant mice showed no reaction to doses as much as 100 times that administered to wild types. Expression analysis of Gb3/CD77 in mouse...
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