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Article

Mutant Escherichia coli heat-labile toxin B subunit that separates toxoid-mediated signaling and immunomodulatory action from trafficking and delivery functions.

Infection and immunity - 1 Mar 2003

Fraser Sylvia A, de Haan Lolke, Hearn Arron R, Bone Heather K, Salmond Robert J, Rivett A Jennifer, Williams Neil A, Hirst Timothy R

Abstract excerpt

The homopentameric B-subunit components of Escherichia coli heat-labile enterotoxin (EtxB) and cholera toxin (CtxB) possess the capacity to enter mammalian cells and to activate cell-signaling events in leukocytes that modulate immune cell function. Both properties have been attributed to the ability of the B subunits to bind to GM1-ganglioside receptors, a ubiquitous glycosphingolipid found in the plasma...

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Source

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Identifiers

PMID: 12595472
DOI: 10.1128/IAI.71.3.1527-1537.2003
PMCID: PMC148879

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Source receipt: pubmed, retrieved 7 Sept 2026.

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