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Staphylococcal Enterotoxin B and C Mutants and Vaccine Toxoids

23 Feb 2023

Abstract excerpt

Toxic shock syndrome toxin 1 (TSST-1) and staphylococcal enterotoxins B and C cause the majority of cases of staphylococcal toxic shock syndrome. Previously, vaccine toxoids of TSST-1 have been prepared. In this study, vaccine toxoids of enterotoxins B and C were prepared. The toxoids lost biological toxicity but were able to vaccinate rabbits against lethal TSS.

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Identifiers

PMID: 36815779
DOI: 10.1128/spectrum.04446-22

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