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Article

Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants.

Structure (London, England : 1993) - 15 Jun 1995

Merritt E A, Sarfaty S, Chang T T, Palmer L M, Jobling M G, Holmes R K, Hol W G

Abstract excerpt

BACKGROUND: Because agents which inhibit the receptor binding of cholera toxin constitute possible lead compounds for the structure-based design of anti-cholera drugs, detailed investigation of the toxin's receptor-binding site is of key importance. The substitution Gly-->Asp at residue 33 of the cholera toxin B subunit (CTB) has been reported to abolish receptor-binding ability. The substitution Arg35-->Asp has...

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PMID: 8590017
DOI: 10.1016/s0969-2126(01)00190-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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