Toxicity and immunogenicity of a verotoxin 1 mutant with reduced globotriaosylceramide receptor binding in rabbits.

doi:10.1128/iai.65.6.2019-2028.1997

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Article

Toxicity and immunogenicity of a verotoxin 1 mutant with reduced globotriaosylceramide receptor binding in rabbits.

Infection and immunity - 1 Jun 1997

Bast D J, Brunton J L, Karmali M A, Richardson S E

Abstract excerpt

The verotoxins (VT1 and VT2), produced by strains of enterohemorrhagic Escherichia coli, have been implicated in the pathogenesis of hemorrhagic colitis and the hemolytic uremic syndrome. To better understand the role of globotriaosylceramide (Gb3) receptor binding by the verotoxins in disease pr...

Topics

Animals
Bacterial Toxins
Escherichia coli
Immunization
Male
Mutation
Rabbits
Shiga Toxin 1
Tissue Distribution
Trihexosylceramides

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