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Article

A duplicated zone of polarizing activity in polydactylous mouse mutants.

Genes & development - 1 Jul 1995

Masuya H, Sagai T, Wakana S, Moriwaki K, Shiroishi T

Abstract excerpt

The positional signaling along the anteroposterior axis of the developing vertebrate limb is provided by the zone of polarizing activity (ZPA) located at the posterior margin. Recently, it was established that the Sonic hedgehog (Shh) mediates ZPA activity. Here we report that a new mouse mutant, Recombination induced mutant 4 (Rim4), and two old mutants, Hemimelic extra toes (Hx) and Extra toes (Xt), exhibit...

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PMID: 7628698
DOI: 10.1101/gad.9.13.1645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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