Article
The basic residue cluster (55)KKWVR(59) in CCL5 is required for in vivo biologic function.
Molecular immunology - 1 Aug 2009
Segerer Stephan, Johnson Zoë, Rek Angelika, Baltus Thomas, von Hundelshausen Philipp, Kungl Andreas J, Proudfoot Amanda E I, Weber Christian, Nelson Peter J
Abstract excerpt
Chemokine function in vivo depends on the presentation by structures of the extracellular matrix or on endothelial surfaces. CCL5 contains two clusters of basic amino acid residues ((44)RKNR(47) and (55)KKWVR(59)) implicated in presentation of the protein. While (44)RKNR(47) has been shown to moderate CCL5 binding to glycosaminoglycans (GAGs), no direct role for the basic residues in the so called 50s loop...
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