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Article

The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle.

The Journal of biological chemistry - 14 Feb 2003

Blanpain Cédric, Doranz Benjamin J, Bondue Antoine, Govaerts Cédric, De Leener Anne, Vassart Gilbert, Doms Robert W, Proudfoot Amanda, Parmentier Marc

Abstract excerpt

CCR5 is a functional receptor for various inflammatory CC-chemokines, including macrophage inflammatory protein (MIP)-1alpha and RANTES (regulated on activation normal T cell expressed and secreted), and is the main coreceptor of human immunodeficiency viruses. The second extracellular loop and a...

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Source

Identifiers

PMID: 12466283
DOI: 10.1074/jbc.M205684200

Genes

CCR5
MIP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12466283-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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