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Article

Evolution of chemokine receptors is driven by mutations in the sodium binding site.

PLoS computational biology - 1 Jun 2018

Taddese Bruck, Deniaud Madeline, Garnier Antoine, Tiss Asma, Guissouma Hajer, Abdi Hervé, Henrion Daniel, Chabbert Marie

Abstract excerpt

Chemokines and their receptors (members of the GPCR super-family) are involved in a wide variety of physiological processes and diseases; thus, understanding the specificity of the chemokine receptor family could help develop new receptor specific drugs. Here, we explore the evolutionary mechanisms that led to the emergence of the chemokine receptors. Based on GPCR hierarchical classification, we analyzed nested...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, CCR5

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Identifiers

PMID: 29912865
DOI: 10.1371/journal.pcbi.1006209
PMCID: PMC6037435

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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