Article
Very strong correlation between dominant negative activities of mutant thyroid hormone receptors and their binding avidity for corepressor SMRT.
The Journal of endocrinology - 1 Dec 2000
Matsushita A, Misawa H, Andoh S, Natsume H, Nishiyama K, Sasaki S, Nakamura H
Abstract excerpt
The syndrome of resistance to thyroid hormone (RTH) is an inherited disorder involving a mutation of the thyroid hormone receptor (TR) gene. Mutant (m) TR inhibits wild-type (wt) TR functions in a dominant negative manner, and this dominant negative effect (DNE) is a crucial factor in RTH pathogenesis. The molecular mechanism of the DNE is still unclear, although several possibilities (including competition...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.