Thyroid hormone resistance: Mechanisms and therapeutic development.

doi:10.1016/j.mce.2022.111679

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Article

Thyroid hormone resistance: Mechanisms and therapeutic development.

Molecular and cellular endocrinology - 1 Aug 2022

Yao Benqiang, Yang Chunyan, Pan Chengxi, Li Yong

Abstract excerpt

As an essential primary hormone, thyroid hormone (TH) is indispensable for human growth, development and metabolism. Impairment of TH function in several aspects, including TH synthesis, activation, transportation and receptor-dependent transactivation, can eventually lead to thyroid hormone resistance syndrome (RTH). RTH is a rare syndrome that manifests as a reduced target cell response to TH signaling. The...

Topics

Humans
Mutation
Receptors, Thyroid Hormone
Thyroid Hormone Receptors alpha
Thyroid Hormone Receptors beta
Thyroid Hormone Resistance Syndrome
Thyroid Hormones
Triiodothyronine

Source

Open in PubMed

Identifiers

PMID: 35738449
DOI: 10.1016/j.mce.2022.111679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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