Article
Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 1997
Yoh S M, Chatterjee V K, Privalsky M L
Abstract excerpt
Nuclear hormone receptors are hormone-regulated transcription factors that play critical roles in chordate development and homeostasis. Aberrant nuclear hormone receptors have been implicated as causal agents in a number of endocrine and neoplastic diseases. The syndrome of Resistance to Thyroid...
Topics
- Cell Line
- Chromosome Mapping
- DNA-Binding Proteins
- Humans
- Models, Molecular
- Mutagenesis, Site-Directed
- Mutation
- Nuclear Receptor Co-Repressor 2
- Phenotype
- Polymorphism, Genetic
- Receptors, Thyroid Hormone
- Repressor Proteins
- Thyroid Hormone Resistance Syndrome
- Transcription, Genetic
- Triiodothyronine