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Article

Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors.

Molecular endocrinology (Baltimore, Md.) - 1 Apr 1997

Yoh S M, Chatterjee V K, Privalsky M L

Abstract excerpt

Nuclear hormone receptors are hormone-regulated transcription factors that play critical roles in chordate development and homeostasis. Aberrant nuclear hormone receptors have been implicated as causal agents in a number of endocrine and neoplastic diseases. The syndrome of Resistance to Thyroid Hormone (RTH) is a human genetic disease characterized by an impaired physiological response to thyroid hormone. RTH is...

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Identifiers

PMID: 9092799
DOI: 10.1210/mend.11.4.9914
PMCID: PMC2725002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors.PMID 9092799Read ↗

Resistance to thyroid hormone (RTH) syndrome reveals novel determinants regulating interaction of T3 receptor with corepressor.Semantic proximity Read ↗

Nuclear corepressors enhance the dominant negative activity of mutant receptors that cause resistance to thyroid hormone.Semantic proximity Read ↗

Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone.Semantic proximity Read ↗

A novel natural mutation in the thyroid hormone receptor defines a dual functional domain that exchanges nuclear receptor corepressors and coactivators.Semantic proximity Read ↗

Transcriptional repression by thyroid hormone receptors. A role for receptor homodimers in the recruitment of SMRT corepressor.Semantic proximity Read ↗

A Novel TRβ Mutation (R383H) in Resistance to Thyroid Hormone Syndrome Predominantly Impairs Corepressor Release and Negative Transcriptional RegulationSemantic proximity Read ↗

Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1).Semantic proximity Read ↗

A resistance to thyroid hormone syndrome mutant operates through the target gene repertoire of the wild-type thyroid hormone receptor.Semantic proximity Read ↗

N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone.Semantic proximity Read ↗

The nuclear corepressors recognize distinct nuclear receptor complexes.Semantic proximity Read ↗

Structural Insights Into Thyroid Hormone ReceptorsSemantic proximity Read ↗

Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors.Semantic proximity Read ↗

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