Article
Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone.
The Journal of biological chemistry - 13 Nov 1998
Safer J D, Cohen R N, Hollenberg A N, Wondisford F E
Abstract excerpt
On positive thyroid hormone response elements (pTREs), thyroid hormone receptor (TR) binding to DNA in the absence of ligand (thyroid hormone, T3) decreases transcription (silencing). Silencing is due to a family of recently described nuclear corepressor proteins (NCoR and SMRT) which bind to the...
Topics
- DNA
- Dimerization
- Electrophoresis, Polyacrylamide Gel
- Histone Acetyltransferases
- Humans
- Ligands
- Mutagenesis, Site-Directed
- Mutation
- Nuclear Proteins
- Nuclear Receptor Co-Repressor 1
- Nuclear Receptor Coactivator 1
- Receptors, Steroid
- Receptors, Thyroid Hormone
- Repressor Proteins
- Thyroid Hormone Resistance Syndrome
- Transcription Factors
- Triiodothyronine