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Article

Resistance to thyroid hormone (RTH) syndrome reveals novel determinants regulating interaction of T3 receptor with corepressor.

Molecular and cellular endocrinology - 25 Jan 2000

Yoh S M, Privalsky M L

Abstract excerpt

Thyroid hormone receptors (T3Rs) both repress and activate gene transcription by interacting with auxiliary factors denoted corepressors and coactivators. Resistance to thyroid hormone (RTH) syndrome in humans is manifested as a failure to respond properly to elevated circulating thyroid hormone. RTH syndrome has been mapped to T3Rbeta mutations that alter the transcriptional properties of the receptor, resulting...

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Identifiers

PMID: 10687857
DOI: 10.1016/s0303-7207(99)00201-4

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Related research

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Resistance to thyroid hormone (RTH) syndrome reveals novel determinants regulating interaction of T3 receptor with corepressor.PMID 10687857Read ↗

Thyroid hormone resistance syndrome manifests as an aberrant interaction between mutant T3 receptors and transcriptional corepressors.Semantic proximity Read ↗

A Novel TRβ Mutation (R383H) in Resistance to Thyroid Hormone Syndrome Predominantly Impairs Corepressor Release and Negative Transcriptional RegulationSemantic proximity Read ↗

Transcriptional repression by thyroid hormone receptors. A role for receptor homodimers in the recruitment of SMRT corepressor.Semantic proximity Read ↗

A novel natural mutation in the thyroid hormone receptor defines a dual functional domain that exchanges nuclear receptor corepressors and coactivators.Semantic proximity Read ↗

A role for helix 3 of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone.Semantic proximity Read ↗

Three novel mutations at serine 314 in the thyroid hormone beta receptor differentially impair ligand binding in the syndrome of resistance to thyroid hormone.Semantic proximity Read ↗

A natural transactivation mutation in the thyroid hormone beta receptor: impaired interaction with putative transcriptional mediators.Semantic proximity Read ↗

A resistance to thyroid hormone syndrome mutant operates through the target gene repertoire of the wild-type thyroid hormone receptor.Semantic proximity Read ↗

Structural Insights Into Thyroid Hormone ReceptorsSemantic proximity Read ↗

Nuclear corepressors enhance the dominant negative activity of mutant receptors that cause resistance to thyroid hormone.Semantic proximity Read ↗

Defective release of corepressor by hinge mutants of the thyroid hormone receptor found in patients with resistance to thyroid hormone.Semantic proximity Read ↗

Thyroid hormone resistance: Mechanisms and therapeutic development.Semantic proximity Read ↗

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