Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2.

Circulation research - 26 Nov 2004

Ohtsubo Toshio, Rovira Ilsa I, Starost Matthew F, Liu Chengyu, Finkel Toren

Abstract excerpt

Xanthine oxidoreductase (XOR) is the enzyme responsible for the final step in purine degradation resulting in the generation of uric acid. Here we have generated mice deficient in XOR. As expected, these animals lack tissue XOR activity and have low to undetectable serum levels of uric acid. Alth...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Urea Nitrogen
Share to Cyclooxygenase 2
Share to Enzyme Induction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kidney Diseases

Share to NIH 3T3 Cells

Share to Prostaglandin-Endoperoxide Synthases

Share to Uric Acid

Share to Xanthine Oxidase

Source

Identifiers

PMID: 15528468
DOI: 10.1161/01.RES.0000149571.96304.36

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15528468-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Xanthine oxidoreductase is an endogenous regulator of cyclooxygenase-2.PMID 15528468Read ↗

Emerging Roles of Xanthine Oxidoreductase in Chronic Kidney DiseaseSemantic proximity Read ↗

The nitrite reductase activity of xanthine oxidoreductase sustains cardiovascular healthSemantic proximity Read ↗

Chronic kidney disease and reduced renal COX2 expression in xanthinuria: a case-control studySemantic proximity Read ↗

A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation.Semantic proximity Read ↗

Untargeted plasma metabolite profiling reveals the broad systemic consequences of xanthine oxidoreductase inactivation in mice.Semantic proximity Read ↗

Genetic susceptibility to diabetic kidney disease is linked to promoter variants of XOR.Semantic proximity Read ↗

NADPH oxidase 5 and renal disease.Semantic proximity Read ↗

Cross regulation between the molecular clock and kidney inflammatory, metabolic and fibrotic responsesSemantic proximity Read ↗

Potential Opportunities for Pharmacogenetic-Based Therapeutic Exploitation of Xanthine Dehydrogenase in Cardiovascular DiseaseSemantic proximity Read ↗

Matrix Metalloproteinase-2 Knockout and Heterozygote Mice Are Protected from Hydronephrosis and Kidney Fibrosis after Unilateral Ureteral Obstruction.Semantic proximity Read ↗

Targeting Liver Xor by GalNAc-siRNA Is an Effective Strategy for Hyperuricemia TherapySemantic proximity Read ↗

Knockout of the urate oxidase gene provides a stable mouse model of hyperuricemia associated with metabolic disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.