Article
Lack of endothelial nitric-oxide synthase leads to progressive focal renal injury.
The American journal of pathology - 1 Jan 2007
Forbes Michael S, Thornhill Barbara A, Park Matthew H, Chevalier Robert L
Abstract excerpt
Because endothelial nitric-oxide synthase (eNOS) is generally considered protective against renal injury, we examined eNOS knockout mice for kidney pathology. In 80% of the adults examined, the renal surface was marked by distinct indented scars containing crowded small glomeruli but lacking attached tubules. Although vasculature was intact in the scars, Bowman's space was dilated and glomerular tufts were...
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