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Article

Defective expression of Tamm-Horsfall protein/uromodulin in COX-2-deficient mice increases their susceptibility to urinary tract infections.

American journal of physiology. Renal physiology - 1 Jul 2005

Dou Wenkai, Thompson-Jaeger Sandra, Laulederkind Stanley J F, Becker John W, Montgomery Julia, Ruiz-Bustos Eduardo, Hasty David L, Ballou Leslie R, Eastman P Scott, Srichai Betsy, Breyer Matthew D, Raghow Rajendra

Abstract excerpt

Mice lacking a functional cyclooxygenase-2 (COX-2) gene develop abnormal kidneys that contain hypoplastic glomeruli and reduced proximal tubular mass, and they often die of renal failure. A comparison of kidney-specific gene expression between wild-type and COX-2-deficient mice by cDNA microarrays revealed that although more than 500 mRNAs were differentially expressed between the two strains of mice depending on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15741608
DOI: 10.1152/ajprenal.00134.2004

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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