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Article

A non-cleavable UmuD variant that acts as a UmuD' mimic.

The Journal of biological chemistry - 7 Apr 2006

Beuning Penny J, Simon Sharotka M, Zemla Adam, Barsky Daniel, Walker Graham C

Abstract excerpt

UmuD(2) cleaves and removes its N-terminal 24 amino acids to form UmuD'(2), which activates UmuC for its role in UV-induced mutagenesis in Escherichia coli. Cells with a non-cleavable UmuD exhibit essentially no UV-induced mutagenesis and are hypersensitive to killing by UV light. UmuD binds to the beta processivity clamp ("beta") of the replicative DNA polymerase, pol III. A possible beta-binding motif has been...

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PMID: 16464848
DOI: 10.1074/jbc.M511101200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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