Article
Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility.
Molecular and cellular biology - 1 Jan 2001
Zhang S L, DuBois W, Ramsay E S, Bliskovski V, Morse H C, Taddesse-Heath L, Vass W C, DePinho R A, Mock B A
Abstract excerpt
The susceptibility of BALB/c mice to pristane-induced plasmacytomas is a complex genetic trait involving multiple loci, while DBA/2 and C57BL/6 strains are genetically resistant to the plasmacytomagenic effects of pristane. In this model system for human B-cell neoplasia, one of the BALB/c susceptibility and modifier loci, Pctr1, was mapped to a 5.7-centimorgan (cM) chromosomal region that included Cdkn2a, which...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.