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Article

Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.

Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 1998

Zhang S, Ramsay E S, Mock B A

Abstract excerpt

Plasma cell tumor induction in mice by pristane is under multigenic control. BALB/c mice are susceptible to tumor development; whereas DBA/2 mice are resistant. Restriction fragment length polymorphisms between BALB/c and DBA/2 for Cdkn2a(p16) and Cdkn2b(p15), and between BALB/c and Mus spretus f...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 9482902
DOI: 10.1073/pnas.95.5.2429
PMCID: PMC19364

Genes

CDK4
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-9482902-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16INK4a and p19ARF, is a candidate for the plasmacytoma susceptibility locus, Pctr1.PMID 9482902Read ↗

Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility.Semantic proximity Read ↗

p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB.Semantic proximity Read ↗

The plasmacytoma resistance gene, Pctr2, delays the onset of tumorigenesis and resides in the telomeric region of chromosome 4.Semantic proximity Read ↗

The role of p16INK4a (Cdkn2a) in mouse plasma cell tumors.Semantic proximity Read ↗

Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene.Semantic proximity Read ↗

Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis.Semantic proximity Read ↗

<i>INK4</i> locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoformSemantic proximity Read ↗

The combination of two Sle2 lupus-susceptibility loci and Cdkn2c deficiency leads to T-cell-mediated pathology in B6.Fas(lpr) mice.Semantic proximity Read ↗

BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice.Semantic proximity Read ↗

Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6.Semantic proximity Read ↗

Fine mapping and characterization of candidate lung tumor resistance genes for the Par2 locus on mouse chromosome 18.Semantic proximity Read ↗

The tumor suppressor protein p16INK4a.Semantic proximity Read ↗

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