Article
Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene.
Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2003
Bliskovsky Valery, Ramsay Edward S, Scott John, DuBois Wendy, Shi Wei, Zhang Shuling, Qian Xiaolan, Lowy Douglas R, Mock Beverly A
Abstract excerpt
Susceptibility to mouse plasmacytomagenesis is a complex genetic trait controlled by several Pctr loci (Pctr1, Pctr2, etc). Congenic strain analysis narrowed the genetic interval surrounding the Pctr2 locus, and genes identified in the interval were sequenced from susceptible BALB/c and resistant DBA/2 mice. Frap (FKBP12 rapamycin-associated protein, mTOR, RAFT) was the only gene differing in amino acid sequence...
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