Article
p16 INK4a gene promoter variation and differential binding of a repressor, the ras-responsive zinc-finger transcription factor, RREB.
Oncogene - 17 Apr 2003
Zhang Shuling, Qian Xiaolan, Redman Chanelle, Bliskovski Valeri, Ramsay Edward S, Lowy Douglas R, Mock Beverly A
Abstract excerpt
BALB/c mice are susceptible to the development of pristane-induced plasma cell tumors, and have a rare allelic variant in the coding region of the p16(INK4a) (p16) tumor suppressor gene that produces a protein with impaired activity. We have now found that the BALB/c p16 promoter has an allelic variant that may also compromise p16 activity. Following pristane treatment, BALB/c p16 mRNA levels in B cells were...
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